Reema is the Director of Self Employed Women's Association (SEWA) and has been working with them for more than 39 years. During this time, she expanded its membership to over 3.2 million members and has made it the single largest union of informal sector women workers.

Reema oversees 4,813 self-help groups, 160 co-operatives and 15 economic federations across 18 states in India and seven South-Asian countries. All of them focus on women’s economic empowerment by building women-owned enterprises and women-led supply chains, introducing modern ICT-based tools and facilitating Green-Energy initiatives and livelihoods. Reema is also a member of the World Bank's Advisory committee and a gender lead in the working group for the UN's Food System Summit's working group.